Aristolochic Acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

马兜铃酸是一类致癌、致突变和肾毒性化合物，常见于马兜铃草（马兜铃科）植物中。

Aristolochic acids are a family of carcinogenic, mutagenic, and nephrotoxic compounds commonly found in the Birthwort (Aristolochiaceae) family of plants.

Cell Viability Assay Cell Line:Kidney cells (HEK 293 and HK-2) Concentration:50, 100, 150, 200 μM Incubation Time:24 hoursResult:The cell viabilities of HEK293 and HK-2 were lower than that of vehicle-treated cultures until 150?μM and 200?μM.RT-PCRCell Line:Kidney cells (HEK 293 and HK-2), and bladder cancer cell line (HT-1376 )Concentration:100, 200 μM Incubation Time:24 hours Result:Down regulated the levels of BLCAP mRNA.Western Blot Analysis Cell Line:HEK293 and HT-1376 cells Concentration:100, 200 μM Incubation Time:24 hours Result:Reduced the BLCAP protein expression in a dose-dependent manner.

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Aristolochic Acid A | Aristolochic acid I | NSC 11926 | NSC 50413 | Tardolyt

Others

Other Targets

Others

Other Indications

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313-67-7

341.27

C17H11NO7

>98% (HPLC)

DMSO: 10 mM

O=C(C1=CC(OCO2)=C2C3=C4C=CC=C(OC)C4=CC([N+]([O-])=O)=C13)O

8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years